Endocrine Abstracts

The androgen receptor (AR) is a steroid-hormone receptor that plays a crucial role in the normal development of male reproductive tissues. Its high expression and/or relaxation of its regulation are strongly implicated in prostate cancer (PCa). Androgen binding induces conformational changes of AR that influence its subcellular localization, interactions with other proteins, DNA binding and transcriptional activity. Androgen dependent is also AR(S81) phosphorylation. Phosphory...